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High-throughput imaging for cancer research applications

PhD project - Ruth Sims
Her project is: High throughput imaging for cancer research applications. In this project we have focused on applications that are severely limited by image acquisition times. In particular, in collaboration with CRUK:CI, we have identified higher throughput of imaging of large cleared tissue as pressing need.
Imaging large (10s of mm) cleared tissue can take 10-20 hours on a point scanning confocal microscope. Designing and constructing an upright light sheet microscope for automated imaging  has led to a 10 fold reduction in imaging times, with large intestinal adenocarcinomas being imaged in 90 minutes rather than 12 hours.
With design and construction of the microscope complete the next phase is to optimised the image acquisition software and analysis.