Quantitative study of cell proliferation and fate choice in zebrafish retina

The study shows that retinal stem cells reside at the extreme peripheral edge of the CMZ, and that as the retina develops, they divide increasingly asymmetrically in the radial orientation.

The orientation of cell division planes with respect to the ciliary marginal zone (CMZ) is computed as schematically shown in fig.1.
 

 Fig. 1: Computation of cell division orientation with respect to CMZ
 

Several statistics related to cell divisions and their geometrical properties are computed and visualised (fig.2)

 Fig. 2: Cell division statistics

Collaboration with Harris group