Multi-modal imaging for assessing chemical intervention in biological systems.

The aim of this project is to explore new imaging techniques and protocols to maximise the information that can be gained from biological systems under chemical intervention. This project is run in collaboration with Meritxell Huch and GlaxoSmithKline through a BBSRC CASE studentship.

In a very early phase we are exploring the use of light sheet and 2-photon scanning microscopy for imaging organoids in timelapse imaging over several days.

Below: light sheet image of liver organoid labelled with the FUCCI system. FUCCI is a genetically encoded two color (red and green) indicator that allows tracking of the cell cycle stage