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Cambridge Advanced Imaging Centre

 

Kevin O'Holleran

Director

Kevin O'Holleran is a physicist with 14 years experience working in the field of advanced light shaping; from esoteric laser manipulation to more applied shaping for super-resolution microscopy. He was the first to successfully embed an isolated knotted singularity into a laser beam and to discover the equations that determine the topology of simple wave superpositions. Since being appointed in 2013 Kevin has enhanced CAIC's capability, offering a full suite of super-resolution imaging modalities, both turn-key commercial microscopes and custom developed systems. His own research continues to focus on advanced bioimaging with a particular emphasis of collaboration and application. Recent successes have been single molecule imaging of the dynamics of transcription factors in living drosophila tissue and the improvement of 3D super-resolution methods through computational imaging.

Karin Müller

Lead Electron Microscopist

Karin Müller is a cell biologist and has joined CAIC from the Department of Chemistry, Cambridge. Her own research has focused on nanoparticle cytotoxicity and mechanisms of extracellular matrix calcification and she therefore has ample experience of imaging specimens at the biological-material interface. Karin and her team will facilitate your TEM and SEM projects by advising on optimal specimen preparation techniques and appropriate imaging/analytical modalities for your particular research questions here at CAIC and in liaison with other electron microscopy facilities in Cambridge.

Leila Muresan 

Research Software Engineer Fellow

Leila Mureșan joined CAIC from the Centre de Génétique Moléculaire in Gif-sur-Yvette. As a Scientific Software Engineer her expertise in image processing and data analysis will be crucial in building the infrastructure and algorithms required to fully exploit the capabilities of our light sheet microscopes.

Martin O. Lenz 

Senior Research Associate

Martin O. Lenz joined the centre from Institute of Neuroscience in Bordeaux, where he developed and applied various super-resolution microscopy techniques. He worked in several postdoctoral and engineering positions (University of Chicago, Imperial College London, IINS Bordeaux) developing and applying various leading edge microscopy technologies. His expertise in optical physics as well as the experience working in interdisciplinary teams will help to fulfil the centres mission.

Filomena Gallo

Senior Technician

Filomena has a background in materials science, with experience in a range of micro-analytical techniques for the characterisation of inorganic materials.
With knowledge of electron microscopy sample preparation, imaging and X-ray microanalysis (EDS and WDS), Filomena has joined CAIC in 2018. Since then she has rapidly acquired experience on routine techniques for the preparation of biological specimens for EM such as staining, resin embedding and ultramicrotomy sectioning. She is currently focused on gaining experience with automated serial sectioning and 3-D imaging. Having worked as a research technician for several years, Filomena has extensive experience in all aspects of laboratory practical work and management, including training of research/students and Health and Safety procedures.

Sohaib Abdul Rehman

Post-doctoral Research Associate

Sohaib is exploring super resolution 'beyond the coverslip' through modelling light propagation and adaptive optics. Through a better understanding of the effect the light path has on the point spread function of a system super resolution techniques can be made to work deeper into thick specimens. 

Bogdan Toader

Post-doctoral Research Associate

Bogdan is working on reconstruction of lightsheet imaging data in the framework of the project 'Scalable image enhancement for light-sheet microscopy: space varying deconvolution and image fusion'.  

Flaminia Kalunthantridge-Don

PhD Student

The aim of Flaminia's project is to develop and characterise 3D liver models for investigating drug toxicity. This project is run in collaboration with Huch Lab and GlaxoSmithKline through a BBSRC CASE studentship.

Ahsan Memon

PhD Student

Ahsan is developing an advanced photo-manipulation microscope with a focus on optical trapping and fast live imaging. He will be using this platform to probe cell mechanics to aid in the understanding of the cell cortex.

Adam Clark

PhD Student

Adam is part of the Lee Lab in the department of Chemistry and is co-supervised by Dr O'Holleran. Adam is developing a new type of 3D super-resolution microscopy which will enable whole-cell imaging without the need for scanning or complex data fusion. This will be achieved through the application of computation imaging concepts to Single Molecule Localisation Microsocpy

Sarah Benaissa

PhD Student

Sarah has joined CAIC for a three year PhD through the Integrated Photonics and Electronics Systems CDT. Sarah will be exploring the potential of lightfield microscopy for super-resolution through simulation and design of novel microlens arrays.

Alex Collins

PhD Student

Alex, also joining from the Integrated Photonics and Electronics Systems CDT, is part of the Lee Lab in the department of Chemistry. He will be exploring approaches for faster throughput and increased information in Single Molecule Localisation Microscopy.


 

Alumni

Ruth Sims

CAIC's first PhD student is Ruth Sims who is building a light sheet microscope with high throughput capabilities for cancer research applications. Ruth is affiliated with the centre for doctoral training in Photonic Systems Development and gained her bachelors degree in Mathematics and Physics from Durham University.