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Cambridge Advanced Imaging Centre

 

As the Director of CAIC and the SBS Microscopy Network, Lisa-Maria, along with a team, oversees Microscopy provision across the School of Biological Sciences.

Her main academic interests are in developing advanced microscopes, methods and other technology to support the diversity of biological study in the University and beyond. Specific research interests include:

Ultra-sensitive methods for label-free molecular measurements in the solution phase

Custom fluorescent probes and optical microscopes for single-molecule, super-resolution imaging

 

Publications

Key publications: 
  1. Needham, L.-M., et al., Label-free detection and profiling of individual solution-phase molecules, Nature, 2024. https://doi.org/10.1038/s41586-024-07370-8
  2. Gorka, F., Daly, S., Pearson, C.M., Bulovaite, E., Handa, A., Grant, S.G., Snaddon, T.S.*, Needham, L.-M.*, Lee, S.F.*- A Comparative Study of High-Contrast Fluorescence Lifetime Probes for Imaging Amyloid in Tissue, The Journal of Physical Chemistry B, 2021. https://doi.org/10.1021/acs.jpcb.1c07762
  3. Needham, L.-M., et al., A Comparative Photophysical Study of Structural Modifications of Thioflavin T-Inspired Fluorophores, The Journal of Physical Chemistry Letters, 2020. https://doi.org/10.1021/acs.jpclett.0c01549
  4. Needham, L.-M.*, Weber, J.*, et al., ThX – a next-generation probe for the early detection of amyloid aggregates, Chemical Science, 2020. https://doi.org/10.1039/C9SC04730A
  5. Needham, L.-M.*, Basu, S.*, et al., FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells, Nature Communications, 2018. https://doi.org/10.1038/s41467-018-04486-0
  6. Needham, L.-M.*, Weber, J.*, et al., Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species, Royal Society Open Science, 2018. https://doi.org/10.1098/rsos.17139
Other publications: 

For a complete list please visit the links below:

Google Scholar

ORCid